![]() ![]() An androgen action particularly important to neurodegenerative diseases is neuroprotection. Androgens induce numerous beneficial neural effects relevant to a protective role against AD, including reduction of the AD-related protein β-amyloid (Aβ) and promotion of synapse formation, neurogenesis, and specific aspects of cognition. In brain, low testosterone is an established factor for the development of Alzheimer’s disease (AD). The decline in testosterone levels in men during normal aging increases risks of dysfunction and disease in androgen-responsive tissues, including brain. Androgens induce numerous beneficial neural effects A similar result was achieved also in the 1.0 mg / kg dose group. In this study, a mean weight gain of greater than 10% in just 28 days of dosing was achieved at a dose of just 0.1 mg/kg. The results on animal body weight of 28-day dosing with RAD140 at 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg are shown in the following figure: RAD140 effectively stimulates the growth of muscle mass RAD140 effectively stimulates the growth of muscle massĪ clinical study published in 2011 examined the anabolic androgenic effect of RAD140 in young primates, male cynomolgous monkeys. In vitro functional androgen agonist activity was confirmed in the C2C12 osteoblast differentiation assay, where an EC50 of 0.1 nM was shown (DHT = 0.05 nM). RAD140 demonstrated excellent affinity for the androgen receptor (Ki = 7 nM versus 29 nM for testosterone and 10 nM for dihydrotestosterone (DHT)) as well as good selectivity over other steroid hormone nuclear receptors, with the closest off target receptor being the progesterone receptor (IC50 = 750 nM vs 0.2 nM for progesterone). RAD140 (Testolone) chemical structure RAD140 has excellent affinity for the androgen receptor as a future substitute of exogenous Testosterone replacement therapy (TRT). Current RAD140 research focuses on its potential benefits in increasing muscle mass, fighting muscle wasting, skeleton wasting (osteoporosis), breast cancer and protecting brain cells. RAD140 Testolone has chemical formula C 20 H 16 Cl N 5 O 2 and molecular mass 393.83 g RAD140 (Testolone) is a potent, orally bioavailable, investigational nonsteroidal selective androgen receptor modulator (SARM) devoloped by Radius Health, Inc.
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